Cible thérapeutique
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Notes et références
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- ↑ a b et c GRCh38: Ensembl release 89: ENSG00000015520 - Ensembl, May 2017
- ↑ a b et c GRCm38: Ensembl release 89: ENSMUSG00000020447 - Ensembl, May 2017
- ↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
- ↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
- ↑ Davis HR Jr, Zhu LJ, Hoos LM et al. Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis, J Biol Chem, 2004;279:33586-33592
- ↑ Temel RE, Tang W, Ma Y et al. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe, J Clin Invest, 2007;117:1968–1978
- ↑ The Myocardial Infarction Genetics Consortium Investigators, Inactivating mutations in NPC1L1 and protection from coronary heart disease, N Engl J Med, 2014;371:2072-2082
- ↑ Lauridsen BK, Stender S, Frikke-Schmidt R, Nordestgaard BG, Tybjærg-Hansen A, Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease, Eur Heart J, 2015;36:1601-1608
- ↑ Garcia-Calvo M, Lisnock J, Bull HG et al. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1), Proc Natl Acad Sci U S A, 2005;102:8132-8137