Facteur de croissance des hépatocytes

Le facteur de croissance des hépatocytes (Hepatocyte growth factor, HGF) est un facteur de croissance, agent mitogène des hépatocytes (cellules du foie). Il se lie au récepteur tyrosine kinase c-met (MET). Son gène est le HGF situé sur le chromosome 7 humain.

HGF
Structure de la protéine HGF. Basé sur l'identifiant PDB 1BHT.
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1BHT, 1GMN, 1GMO, 1GP9, 1NK1, 1SHY, 1SI5, 2HGF, 2QJ2, 3HMS, 3HMT, 3HN4, 3MKP, 3SP8, 4K3J, 4O3T, 4O3U, 5COE, 5CP9, 5CS1, 5CS3, 5CS5, 5CS9, 5CSQ, 5CT1, 5CT2, 5CT3, 4D3C
Identifiants
Aliases	HGF, Facteur de croissance des hépatocytes
IDs externes	OMIM: 142409 MGI: 96079 HomoloGene: 503 GeneCards: HGF
Position du gène (Homme) Chr. Chromosome 7 humain Locus 7q21.11 Début 81,699,010 bp Fin 81,770,438 bp
Position du gène (Souris) Chr. Chromosome 5 (souris) Locus 5 A3|5 7.07 cM Début 16,758,493 bp Fin 16,825,150 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans placenta stromal cell of endometrium pleura viscéral buccal mucosa cell monocyte pancreatic epithelial cell vésicule biliaire Epithelium of choroid plexus foie artère coronaire droite Fortement exprimé dans lumbar spinal ganglion granulocyte urètre strie vasculaire tubercule génital embryon primitive endoderm glande pinéale paroi abdominale lobe pulmonaire droit Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire liaison protéique identical protein binding chemoattractant activity protein heterodimerization activity growth factor activity serine-type endopeptidase activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Composant cellulaire membrane région extracellulaire platelet alpha granule lumen milieu extracellulaire Processus biologique negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of hydrogen peroxide-mediated programmed cell death positive regulation of neuron projection regeneration positive regulation of interleukin-10 production positive regulation of cell migration cellular response to hepatocyte growth factor stimulus negative regulation of release of cytochrome c from mitochondria negative regulation of interleukin-6 production platelet degranulation negative regulation of apoptotic process regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling positive regulation of angiogenesis positive regulation of myelination positive regulation of osteoblast differentiation myoblast proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors animal organ regeneration cell morphogenesis positive regulation of cell population proliferation hyaluronan metabolic process positive regulation of DNA biosynthetic process negative regulation of peptidyl-serine phosphorylation Transition épithélio-mésenchymateuse positive regulation of peptidyl-tyrosine phosphorylation cell chemotaxis liver development positive regulation of phosphatidylinositol 3-kinase signaling regulation of p38MAPK cascade prolifération cellulaire negative regulation of autophagy hepatocyte growth factor receptor signaling pathway negative regulation of inflammatory response positive regulation of transcription by RNA polymerase II regulation of tau-protein kinase activity protéolyse positive chemotaxis MAPK cascade peptidyl-tyrosine phosphorylation phosphatidylinositol phosphate biosynthetic process mitose regulation of signaling receptor activity positive regulation of protein kinase B signaling positive regulation of protein phosphorylation cytokine-mediated signaling pathway epithelial cell proliferation Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 3082 15234 Ensembl ENSG00000019991 ENSMUSG00000028864 UniProt P14210 Q08048 RefSeq (mRNA) NM_000601 NM_001010931 NM_001010932 NM_001010933 NM_001010934 NM_010427 NM_001289458 NM_001289459 NM_001289460 NM_001289461 RefSeq (protéine) NP_000592 NP_001010931 NP_001010932 NP_001010933 NP_001010934 NP_001276387 NP_001276388 NP_001276389 NP_001276390 NP_034557 Localisation (UCSC) Chr 7: 81.7 – 81.77 Mb Chr 5: 16.76 – 16.83 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

Inhibiteurs

• Ficlatuzumab

Bibliographie

• Michalopoulos GK, Zarnegar R, « Hepatocyte Growth Factor », Hepatology, vol. 15, n^o 1,‎ 1992, p. 149–54 (DOI 10.1002/hep.1840150125)
• Nakamura T, « Structure and function of hepatocyte growth factor », Prog. Growth Factor Res., vol. 3, n^o 1,‎ 1992, p. 67–85 (PMID 1838014, DOI 10.1016/0955-2235(91)90014-U)
• Ware LB, Matthay MA, « Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair », Am. J. Physiol. Lung Cell Mol. Physiol., vol. 282, n^o 5,‎ 2002, L924–40 (PMID 11943656, DOI 10.1152/ajplung.00439.2001)
• Funakoshi H, Nakamura T, « Hepatocyte growth factor: from diagnosis to clinical applications », Clin. Chim. Acta, vol. 327, n^os 1–2,‎ 2003, p. 1–23 (PMID 12482615, DOI 10.1016/S0009-8981(02)00302-9)
• Skibinski G, « The role of hepatocyte growth factor/c-met interactions in the immune system », Arch. Immunol. Ther. Exp. (Warsz.), vol. 51, n^o 5,‎ 2004, p. 277–82 (PMID 14626426)
• Kalluri R, Neilson EG, « Epithelial-mesenchymal transition and its implications for fibrosis », J. Clin. Invest., vol. 112, n^o 12,‎ 2004, p. 1776–84 (PMID 14679171, PMCID 297008, DOI 10.1172/JCI20530)
• Hurle RA, Davies G, Parr C, MD Mason, SA Jenkins, HG Kynaston et WG Jiang, « Hepatocyte growth factor/scatter factor and prostate cancer: a review », Histol. Histopathol., vol. 20, n^o 4,‎ 2006, p. 1339–49 (PMID 16136515)
• Kemp LE, Mulloy B, Gherardi E, « Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors », Biochem. Soc. Trans., vol. 34, n^o Pt 3,‎ 2006, p. 414–7 (PMID 16709175, DOI 10.1042/BST0340414)

Liens externes

• (en) MeSH Hepatocyte+growth+factor
• (en) Hepatocyte growth factor on the Atlas of Genetics and Oncology
• (en) UCSD Signaling Gateway Molecule Page on HGF