HDAC4

HDAC4
	Domaine catalytique Hdac4. PDB2vqj
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S
Identifiants
Aliases	HDAC4
IDs externes	OMIM: 605314 MGI: 3036234 HomoloGene: 55946 GeneCards: HDAC4
Position du gène (Homme)
Chr.	Chromosome 2 humain
Fin	239,401,654 bp
Position du gène (Souris)
Chr.	Chromosome 1 (souris)
Fin	92,123,421 bp
Expression génétique
	Fortement exprimé dans
	nerf sural; ; muscle gastrocnémien; ; muscle tibial antérieur; ; cellule endothéliale; ; muscle deltoïde; ; sang; ; ligament alvéolo-dentaire; ; muscle quadriceps fémoral; ; Brodmann area 23; ; germinal epithelium;
	Fortement exprimé dans
	lèvre; ; septum interventriculaire; ; tissu musculaire; ; skeletal muscle tissue; ; muscle quadriceps fémoral; ; aorte ascendante; ; tube neural; ; articulation du genou; ; valve aortique; ; cumulus cell;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; liaison ADN; transcription corepressor activity; histone deacetylase activity; zinc ion binding; transcription factor binding; liaison d'histone déacétylase; potassium ion binding; liaison de chromatine; liaison ion métal; liaison protéique; protein kinase binding; activité hydrolase; protein deacetylase activity; identical protein binding; promoter-specific chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; SUMO transferase activity;
Composant cellulaire	cytoplasme; histone deacetylase complex; Plaque motrice; transcription repressor complex; Sarcomère; Z disc; A band; actomyosin; noyau; cytosol; nucléoplasme; complexe macromoléculaire;
Processus biologique	positive regulation of reactive oxygen species biosynthetic process; histone H3 deacetylation; skeletal system development; Remodelage de la chromatine; peptidyl-lysine deacetylation; regulation of cardiac muscle contraction by calcium ion signaling; negative regulation of glycolytic process; response to interleukin-1; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; cellular response to tumor necrosis factor; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; positive regulation of protein sumoylation; negative regulation of DNA-binding transcription factor activity; negative regulation of osteoblast differentiation; transcription, DNA-templated; neurodéveloppement; regulation of striated muscle cell differentiation; régulation positive de la transcription dépendante de l'ADN; positive regulation of smooth muscle cell migration; B cell activation; histone H4 deacetylation; cellular response to mechanical stimulus; positive regulation of neuron apoptotic process; cardiac muscle hypertrophy in response to stress; positive regulation of cell population proliferation; negative regulation of myotube differentiation; response to denervation involved in regulation of muscle adaptation; regulation of skeletal muscle fiber development; osteoblast development; B cell differentiation; cellular response to parathyroid hormone stimulus; réponse inflammatoire; positive regulation of lamellipodium assembly; regulation of protein binding; negative regulation of transcription, DNA-templated; histone deacetylation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; positive regulation of smooth muscle cell proliferation; organisation de la chromatine; negative regulation of pri-miRNA transcription by RNA polymerase II; protein deacetylation; Sumoylation; positive regulation of male mating behavior;
	Sources:Amigo / QuickGO
Orthologues
	9759
	208727
	ENSG00000068024
	ENSMUSG00000026313
	P56524
	Q6NZM9
	NM_006037; NM_001378414; NM_001378415; NM_001378416; NM_001378417
	NM_207225
	NP_006028; NP_001365343; NP_001365344; NP_001365345; NP_001365346
	NP_997108
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

L'HDAC4 est une histone désacétylase. Son gène est le HDAC4 situé sur le chromosome 2 humain.

Rôles modifier

Elle appartient à la classe II des histones désacétylases.

La protéine est phophorylée par le CaMKII qui en modifie l'activité^[5], entraînant par exemple une hypertrophie des cardiomyocytes^[6]. Elle contrôle également la prolifération et la migration des cellules musculaires lisses^[7] contribuant ainsi à la genèse d'une hypertension artérielle^[8].

Elle régule l'autophagie induite par l'angiotensine 2^[9].

Notes et références modifier

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000068024 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000026313 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Dokmanovic M, Clarke C, Marks PA, Histone deacetylase inhibitors: overview and perspectives, Mol Cancer Res, 2007;5:981–989
↑ Backs J, Song K, Bezprozvannaya S, Chang S, Olson EN, CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy, J Clin Invest, 2006;116:1853–1864
↑ Usui T, Morita T, Okada M, Yamawaki H, Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells, Hypertension, 2014;63:397
↑ Usui T, Okada M, Mizuno W, Oda M, Ide N, Morita T, Hara Y, Yamawaki H, HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats, Am J Physiol-Heart C, 2012;302:H1894–H1904
↑ Yang D, Xiao C, Long F et al. HDAC4 regulates vascular inflammation via activation of autophagy, Cardiovascular Research, 2018;114:1016–1028

Portail de la biologie cellulaire et moléculaire

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000068024 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000026313 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Dokmanovic_2007-5] Dokmanovic M, Clarke C, Marks PA, Histone deacetylase inhibitors: overview and perspectives, Mol Cancer Res, 2007;5:981–989

[Backs_2006-6] Backs J, Song K, Bezprozvannaya S, Chang S, Olson EN, CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy, J Clin Invest, 2006;116:1853–1864

[Usui_2014-7] Usui T, Morita T, Okada M, Yamawaki H, Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells, Hypertension, 2014;63:397

[Usui_2012-8] Usui T, Okada M, Mizuno W, Oda M, Ide N, Morita T, Hara Y, Yamawaki H, HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats, Am J Physiol-Heart C, 2012;302:H1894–H1904

[Yang_2018-9] Yang D, Xiao C, Long F et al. HDAC4 regulates vascular inflammation via activation of autophagy, Cardiovascular Research, 2018;114:1016–1028

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