TGF bêta 2

Le TGFB2 (pour « Transforming growth factor-beta 2 ») en français facteur de croissance transformant 2 est une protéine dont le gène est le TGFB2 situé sur le chromosome 1 humain. Il s'agit de l'un des sous-types des TGF-β.

TGFB2
Structure de la protéine TGFB2. Basé sur l'identifiant PDB 1TFG.
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1TFG, 2TGI, 4KXZ
Identifiants
Aliases	TGFB2, Transforming growth factor-beta 2
IDs externes	OMIM: 190220 MGI: 98726 HomoloGene: 2432 GeneCards: TGFB2
Position du gène (Homme) Chr. Chromosome 1 humain Locus 1q41 Début 218,345,336 bp Fin 218,444,619 bp
Position du gène (Souris) Chr. Chromosome 1 (souris) Locus 1 H5|1 89.95 cM Début 186,354,989 bp Fin 186,438,186 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans tendon calcanéen germinal epithelium sperme Glandes accessoires tibia îlot de Langerhans muscle lisse artère coronaire droite endocol follicule pileux Fortement exprimé dans corps ciliaire iris artère carotide externe secondary oocyte artère carotide interne valve sigmoïde glande submandibulaire atrioventricular canal glande pinéale aorte ascendante Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire type II transforming growth factor beta receptor binding signaling receptor binding type III transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding growth factor activity protein homodimerization activity amyloid-beta binding liaison protéique protein heterodimerization activity Composant cellulaire région extracellulaire matrice extracellulaire platelet alpha granule lumen milieu extracellulaire axone neuronal cell body collagen-containing extracellular matrix Processus biologique développement de l'œil regulation of transforming growth factor beta2 production response to progesterone mort cellulaire cardioblast differentiation positive regulation of integrin biosynthetic process phosphorylation des protéines positive regulation of heart contraction positive regulation of neuron apoptotic process angiogenèse negative regulation of epithelial cell proliferation uterine wall breakdown negative regulation of alkaline phosphatase activity negative regulation of macrophage cytokine production positive regulation of cell adhesion mediated by integrin prolifération cellulaire transforming growth factor beta receptor signaling pathway negative regulation of cell population proliferation positive regulation of stress-activated MAPK cascade cell-cell junction organization extrinsic apoptotic signaling pathway collagen fibril organization positive regulation of epithelial cell migration neutrophil chemotaxis positive regulation of cell growth response to wounding negative regulation of cell growth positive regulation of cardioblast differentiation glial cell migration cicatrisation positive regulation of ossification cardiac muscle cell proliferation positive regulation of epithelial to mesenchymal transition odontogenèse positive regulation of timing of catagen positive regulation of immune response regulation of complement-dependent cytotoxicity positive regulation of protein secretion Transition épithélio-mésenchymateuse embryonic digestive tract development response to hypoxia cell-cell signaling positive regulation of pathway-restricted SMAD protein phosphorylation heart morphogenesis platelet degranulation salivary gland morphogenesis génération des neurones negative regulation of immune response cell morphogenesis positive regulation of cell population proliferation positive regulation of phosphatidylinositol 3-kinase signaling migration cellulaire activation of protein kinase activity positive regulation of cell division cardiac epithelial to mesenchymal transition BMP signaling pathway développement d'une cellule skeletal system development kidney development neural tube closure hair follicle development outflow tract septum morphogenesis membranous septum morphogenesis heart valve morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis neural retina development développement du cœur male gonad development hématopoïèse embryonic limb morphogenesis hair follicle morphogenesis ascending aorta morphogenesis dopamine biosynthetic process positive regulation of cell cycle negative regulation of Ras protein signal transduction division d'une cellule souche somatique développement d'un neurone inner ear development uterus development pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis atrial septum morphogenesis pharyngeal arch artery morphogenesis regulation of apoptotic process involved in outflow tract morphogenesis substantia propria of cornea development cranial skeletal system development negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation regulation of signaling receptor activity negative regulation of gene expression negative regulation of angiogenesis positive regulation of Notch signaling pathway SMAD protein signal transduction positive regulation of pri-miRNA transcription by RNA polymerase II embryo development ending in birth or egg hatching regulation of timing of catagen secondary palate development regulation of cell population proliferation regulation of apoptotic process regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 7042 21808 Ensembl ENSG00000092969 ENSMUSG00000039239 UniProt P61812 P27090 RefSeq (mRNA) NM_003238 NM_001135599 NM_009367 NM_001329107 RefSeq (protéine) NP_001129071 NP_003229 NP_001316036 NP_033393 Localisation (UCSC) Chr 1: 218.35 – 218.44 Mb Chr 1: 186.35 – 186.44 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

Rôle

Il intervient dans la voie de signalisation des Smad.

En médecine

Une mutation de son gène entraîne un anévrisme aortique thoracique dans le cadre d'un syndrome de Loeys-Dietz.