Interleukine 1 bêta

L'interleukine 1 bêta est une isoforme de l'interleukine 1. Elle a un rôle pro-inflammatoire. Son gène est IL1B situé sur le chromosome 2 humain.

IL1B
Structure d'IL-1b créée à l'aide des données de Protein Data Bank (PDB : 31BI)
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP
Identifiants
Aliases	IL1B, Interleukine 1 bêta
IDs externes	OMIM: 147720 MGI: 96543 HomoloGene: 481 GeneCards: IL1B
Position du gène (Homme) Chr. Chromosome 2 humain Locus 2q14.1 Début 112,829,751 bp Fin 112,836,816 bp
Position du gène (Souris) Chr. Chromosome 2 (souris) Locus 2 F1|2 62.97 cM Début 129,206,490 bp Fin 129,213,059 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans ligament alvéolo-dentaire granulocyte monocyte sang cellule de la moelle osseuse cartilage tissue pancreatic ductal cell vésicule biliaire appendice iléo-cæcal Caduque basale Fortement exprimé dans granulocyte sang tibiofemoral joint rate embryon moelle osseuse îlot de Langerhans poumon droit lumbar subsegment of spinal cord ventricule droit Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire protein domain specific binding interleukin-1 receptor binding cytokine activity integrin binding liaison protéique Composant cellulaire cytoplasme cytosol région extracellulaire lysosome exosome secretory granule vésicule milieu extracellulaire Processus biologique positive regulation of protein phosphorylation smooth muscle adaptation positive regulation of calcidiol 1-monooxygenase activity negative regulation of insulin receptor signaling pathway cellular response to mechanical stimulus positive regulation of interleukin-8 production positive regulation of mitotic nuclear division response to carbohydrate implantation de l'embryon regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of cell population proliferation apoptose cellular response to organic substance positive regulation of phagocytosis regulation of insulin secretion neutrophil chemotaxis régulation positive de la transcription dépendante de l'ADN positive regulation of protein export from nucleus positive regulation of prostaglandin secretion positive regulation of myosin light chain kinase activity negative regulation of MAP kinase activity positive regulation of T cell proliferation positive regulation of interleukin-6 production réponse inflammatoire negative regulation of lipid metabolic process sequestering of triglyceride hyaluronan biosynthetic process positive regulation of heterotypic cell-cell adhesion positive regulation of lipid catabolic process cellular response to organic cyclic compound positive regulation of fever generation positive regulation of DNA-binding transcription factor activity positive regulation of angiogenesis response to lipopolysaccharide positive regulation of NF-kappaB transcription factor activity positive regulation of granulocyte macrophage colony-stimulating factor production réponse immunitaire ectopic germ cell programmed cell death leukocyte migration lipopolysaccharide-mediated signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of cell adhesion molecule production response to ATP monocyte aggregation protein kinase B signaling positive regulation of nitric oxide biosynthetic process cell-cell signaling positive regulation of monocyte chemotactic protein-1 production regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of interferon-gamma production MAPK cascade positive regulation of histone acetylation positive regulation of gene expression negative regulation of glucose transmembrane transport interleukin-1 beta production positive regulation of T cell mediated immunity extrinsic apoptotic signaling pathway in absence of ligand positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of vascular endothelial growth factor production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of lipid catabolic process negative regulation of adiponectin secretion regulation of establishment of endothelial barrier positive regulation of cell division transduction de signal positive regulation of transcription by RNA polymerase II cytokine-mediated signaling pathway regulation of defense response to virus by host fever generation positive regulation of JNK cascade positive regulation of cell population proliferation regulation of signaling receptor activity positive regulation of epithelial to mesenchymal transition positive regulation of cell migration interleukin-6 production astrocyte activation régulation de la neurogenèse negative regulation of neurogenesis negative regulation of synaptic transmission positive regulation of glial cell proliferation regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide positive regulation of neuroinflammatory response positive regulation of p38MAPK cascade positive regulation of NIK/NF-kappaB signaling positive regulation of T-helper 1 cell cytokine production positive regulation of prostaglandin biosynthetic process positive regulation of complement activation positive regulation of inflammatory response response to interleukin-1 positive regulation of RNA biosynthetic process Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 3553 16176 Ensembl ENSG00000125538 ENSMUSG00000027398 UniProt P01584 P10749 RefSeq (mRNA) NM_000576 NM_008361 RefSeq (protéine) NP_000567 NP_032387 Localisation (UCSC) Chr 2: 112.83 – 112.84 Mb Chr 2: 129.21 – 129.21 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

Structure

L'interleukine 1 possède deux principales isoformes. L'interleukine 1 alpha est fixée à la cellule tandis que l'interleukine 1 bêta diffuse dans le sang permettant une action à distance.

La protéine est fabriquée sous forme d'une pro-interleukine 1 bêta qui va être clivée par la caspase 1, l'un des composants de l'inflammasome, en interleukine 1 bêta.

Rôles

IL-1β favorise la chimiorésistance dans le cancer et est un acteur clé dans le microenvironnement tumoral.

Elle joue un rôle dans la formation de l'athérome. Son taux sanguin, mesuré lors d'un infarctus du myocarde est corrélé avec un risque plus important de mortalité ou de complications.

Cible thérapeutique

Le canakinumab est un anticorps monoclonal dirigé contre l'interleukine-1 bêta.